Comparative, adaptiveandfunctional skeletal biology

Laizé V, Gavaia PJ, Cancela ML (2014) Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models 13:29-37
http://dx.doi.org/10.1016/j.ddmod.2014.08.001

Cancela ML, Laizé V, Conceição N (2014) Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization. Archives of Biochemistry and Biophysics 561:56-63
http://dx.doi.org/10.1016/j.abb.2014.07.020

Cavaco S, Williamson MK, Rosa J, Roberto V, Cordeiro O, Price PA, Cancela ML, Laizé V, Simes DC (2014) Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Fish Physiology and Biochemistry 40:731-738
http://dx.doi.org/10.1007/s10695-013-9880-9

Fernández I, Santos A, Cancela ML, Laizé V, Gavaia PJ (2014) Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K dependent proteins. Environmental Pollution 194:86-95
http://dx.doi.org/10.1016/j.envpol.2014.07.015

Fernández I, Tiago DM, Laizé V, Cancela ML, Gisbert E (2014) Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: different gene expression of nuclear receptors and ECM proteins. Journal of Steroid Biochemistry & Molecular Biology 140:34-43
http://dx.doi.org/10.1016/j.jsbmb.2013.11.012

Gisbert E, Fernández I, Villamizar N, Darias MJ, Zambonino-Infante JL, Estévez A (2014) European sea bass larval culture. In: Biology of European Sea bass, Sánchez-Vázquez FJ, Muñoz-Cueto JA (Eds). CRC Press, USA (ISBN 978-1-4665-9945-1)

Marques CL, Fernández I, Rosa J, Viegas MN, Cancela ML, Laizé V (2014) Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole. Journal of Applied Ichthyology 30:713-720
http://dx.doi.org/10.1111/jai.12539

Ortiz-Delgado JB, Fernández I, Sarasquete C, Gisbert E (2014) Normal and histopathological organization of the opercular bone and vertebrae in gilthead sea bream Sparus aurata. Aquatic Biology 21:67-84.
http://dx.doi.org/10.3354/ab00568

Richard N, Fernández I, Wulff T, Hamre K, Cancela L, Conceição LEC, Gavaia PJ (2014) Dietary supplementation with vitamin K affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Marine Biotechnology 16:522-537
http://dx.doi.org/10.1007/s10126-014-9571-2

Roberto VP, Tiago DM, Silva I, Cancela ML (2014) miR-29a is an enhancer of mineral deposition in bone-derived systems. Archives of Biochemistry and Biophysics 564:173-183
http://dx.doi.org/10.1016/j.abb.2014.09.006

Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis MT, Panserat S (2014) Glucose overload in yolk has little effects on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Journal of Experimental Biology 217:1139-1149
http://dx.doi.org/10.1242/jeb.095463

Rosa JT, Cancela ML, Laizé V (2014) Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream. Journal of Applied Ichthyology 30:707-712
http://dx.doi.org/10.1111/jai.12534

Silva IAL, Conceição N, Michou L, Cancela ML (2014) Can zebrafish be a valid model to study Paget’s disease of bone? Journal of Applied Ichthyology 30:678-688
http://dx.doi.org/10.1111/jai.12523

Silva IAL, Cox CJ, Leite RB, Cancela ML, Conceição N (2014) Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 172-173:9-20
http://dx.doi.org/10.1016/j.cbpb.2014.03.007

Simões B, Conceição N, Kelsh RN, Cancela ML (2014) Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 gene through an in silico analysis: implications for function. Journal of Applied Ichthyology 30:661-670
http://dx.doi.org/10.1111/jai.12536

Soares F, Fernández I, Costas B, Gavaia P (2014) Non-infectious disorders of warmwater fish. In: Diseases and disorders of finfish in cage culture, 2nd edition, Woo PTH and Bruno DW (Eds). CABI International, Nosworthy Way, Wallingford, UK (ISBN 978-178-0642-079)

Tiago DM, Marques CL, Roberto VP, Cancela ML, Laizé V (2014) Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish. Archives of Biochemistry and Biophysics 543:23-30
http://dx.doi.org/10.1016/j.abb.2013.12.009

Witten PE, Cancela ML (2014) Fish skeletal biology and beyond. Journal of Applied Ichthyology 30:597-599
http://dx.doi.org/10.1111/jai.12506